Latrotoxin, produced by the poisonous black widow spider, increases the release of acetylcholine. how do muscle cells respond?

Latrotoxin produced by widow spider affects muscle nerve endings. This toxin forms pores on the membrane of the cell. As a consequence, an influx of Ca + ions occurs and bursts of the neurotransmitter acetylcholine (Ach) are released. Ach induces an increase in neuromuscular activity that leads to painful skeletal muscle spasms and later even paralysis.