The disease bullous pemphigoid results in the destruction of proteins within the basement membrane that holds the epidermis and dermis together. how would this likely affect the epidermis? would the skin be an effective barrier to this disease?

This would directly affect the epidermis because blisters will develop within the surface of the skin. Having blisters on the epidermis will decrease the function of the skin to be an effective barrier to disease. This is because blisters are open wounds that are prone to infection. As infection passes through these openings, it will affect the dermis and the other layers of the skin. Bullae is actually an auto-immune skin disease.