What can a deficiency of growth hormone during bone formation cause? what can a deficiency of growth hormone during bone formation cause? decreased osteoclast activity inadequate calcification of bone increased osteoclast activity decreased epiphyseal plate activity?

The deficiency of growth hormone during bone formation would cause a decreased proliferation of the epiphyseal plate cartilage. Growth hormone is a peptide hormone secreted by the pituitary gland under the control of the hypothalamus. It directly through IGF-I stimulates osteoblasts proliferation and activity, promoting bone formation. In addition it also stimulates osteoclast differentiation and activity, promoting bone resorption. Therefore, growth hormone is an important hormone in bone formation.