Would a karyotype show an autosomal dominant disorder? Why or why not?

The answer is NO. Karyotypes visualize the structure of condensed chromosomes in the metaphase stage of mitosis. Karyotype is good at diagnosing disorders related to chromosome changes such as aneuploidy. However, disorders such as autosomal dominant cannot be detected by Karyotype since they are caused by nucleotide mutations that do not affect the structure/conformation of the chromosomes.