Chronic myelogenous leukemia (CML) is caused when a segment of chromosome 9 and a segment of chromosome 22 both break off and switch places. What type of mutation is this?

Question

Biology

Bethany Roach

30 June, 11:45

Chronic myelogenous leukemia (CML) is caused when a segment of chromosome 9 and a segment of chromosome 22 both break off and switch places. What type of mutation is this?

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Answers (1)

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Dania Boyd · Answer 1

The correct answer is reciprocal translocation.

Explanation:

Being more specific, the type of reciprocal translocation that is caused when a segment of chromosome 9 and a segment of chromosome 22 both break off and switch places is The Philadelphia chromosome.

What happens here is that a part of chromosome 9 translocates to chromosome 22, once there it takes the place of a part of fragment 22, which will be translocated to chromosome 9. The latter is what is known as the Philadelphia chromosome.

In the case of this type of genetic mutation, this type of chromosome is the most famous in terms of malignant diseases and is carried by 90% of people with chronic myelogenous leukemia, being discovered in the year 1960.