g Which factors are associated with sickling of red blood cells in sickle cell disease? high O 2 O2 concentration high temperature dehydration low pH

sudden change in temperature, which can make the blood vessels narrow.

very strenuous or excessive exercise, due to shortage of oxygen.

dehydration, due to low blood volume.

infections.

stress.

high altitudes, due to low oxygen concentrations in the air.

alcohol.

smoking.

Explanation:

Any event that can lead to acidosis, such as infection or extreme dehydration, can cause sickling. More benign factors and environmental changes, such as fatigue, exposure to cold, and psychosocial stress, can elicit the sickling process.

Answer: Low O2 Concentration

Explanation:

In a condition of low oxygen (O2) concentration, the hemoglobin of red blood cells break down causing the cells to become sickle-shaped. Such red blood cells block the cavities of small blood vessels in the body thereby hindering the free flow of blood in them.

Thus, the body parts of such person affected receives insufficient blood, oxygen and nutrients leading to crisis