As the size of a cell increases

a. Its metabolic demands increase.

b. It's surface area-to-volume ratio decreases.

c. Its ability to transport enough nutrients in and transport wastes out to meet cellular metabolic demands decreases.

d. Its surface area to volume ratio increases

The correct answers are-

a. Its metabolic demands increase.

b. It's surface area-to-volume ratio decreases.

c. Its ability to transport enough nutrients in and transport wastes out to meet cellular metabolic demands decreases.

Explanation:

As the size of a cell increases the surface area to volume ratio decrease. So a big cell has less surface area and small volume. Therefore surface area for transfer of metabolic substance per unit volume decreases so the cell's ability to transport enough nutrients in and transport wastes out to meet cellular metabolic demands also decreases.

But due to an increase in the volume of the cell the metabolic demand of cell increases because a larger cell requires more nutrients than a smaller cell to survive which can not be fulfilled efficiently due to less surface-area-to-volume ratio.

Therefore the correct answer is a, b, and c.