A 34-year-old woman with ulcerative colitis has required long-term treatment with pharmacologic doses of a glucocorticoid agonist. Which of the following is a toxic effect associated with long-term glucocorticoid treatment?
(A) A lupus-like syndrome
(B) Adrenal gland neoplasm
(C) Hepatotoxicity
(D) Osteoporosis
(E) Precocious puberty in children
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