What would have happened if Avery had added an enzyme that digested all the nucleic acids to the mixture of heat-killed bacteria, added the mixture to harmless bacteria, and injected the mixture into mice?

In the Avery experiment, it was proved that the genetic material is DNA not protein.

The key components of the Griffith Experiment, in which the mice was injected with live bacteria of one strain and dead bacteria of another strain.

The disease was developed in the species of mice infected with dead bacterial strain.

If the enzyme would have digested all the nucleic acid then the mice would have not transformed because the nucleic acid would have been destroyed.