Long‑chain fatty acids are activated in the cytosol, but they are oxidized in mitochondria. Three enzymes enable the transport of activated long‑chain fatty acids across the inner mitochondrial membrane. Classify each of the enzyme locations or functions as describing carnitine acyltransferase I (CAT I), translocase, or carnitine acyltransferase II (CAT II).

a. transfers an acyl group to carnitine

b. located on the cytoplasmic side of the mitochondrial membrane

c. shuttles acyl carnitine across the inner mitochondrial membrane

d. regenerates carnitine and acyl COA

e. located on the matrix side of the inner mitochondrial membrane

f. shuttles carnitine across the inner mitochondrial membrane

Question

Biology

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4 January, 08:35

Long‑chain fatty acids are activated in the cytosol, but they are oxidized in mitochondria. Three enzymes enable the transport of activated long‑chain fatty acids across the inner mitochondrial membrane. Classify each of the enzyme locations or functions as describing carnitine acyltransferase I (CAT I), translocase, or carnitine acyltransferase II (CAT II).

a. transfers an acyl group to carnitine

b. located on the cytoplasmic side of the mitochondrial membrane

c. shuttles acyl carnitine across the inner mitochondrial membrane

d. regenerates carnitine and acyl COA

e. located on the matrix side of the inner mitochondrial membrane

f. shuttles carnitine across the inner mitochondrial membrane

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Answers (1)

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Jovani York · Answer 1

The options a, c and e matches with carnitine acyltransferase I.

The enzyme carnitine acyltransferase I is situated on the inner mitochondrial membrane's matrix end. It performs the functions of transferring an acyl group to carnitine and shuttles acyl carnitine through the mitochondria's inner membrane.

The options b and f correctly matches with translocase.

Translocase is situated on the mitochondrial membrane's cytoplasmic end. It performs the function of shuttling carnitine through the mitochondria's inner membrane.

The option d correctly matches with carnitine acyltransferase II. The enzyme carnitine acyltransferase II performs the function of regenerating carnitine and acetyl CoA.