How digestive enzyme affected when people having high fever? Explain.

When a person has high fever, it's body temperature increases.

When the temperature is too high, enzyme molecules vibrate vigorously causing it to lost it's shapes and active sites.

Then, started to denatured and eventually, the enzyme died and no longer able to function.

Higher the body temperature, it would disrupt the shape of the active site of the enzyme, which will reduce its activity, or prevent it from working. The enzyme will have been denatured also the protein which can also lead to death.