For the nucleotide sequence AAC (O6-meG) TGCAC, with a damaged (methylated) G residue, what would be the sequence of each strand of the double-stranded DNA in the following situations? a) Replication occurs before repairb) The DNA is acted upon by glycosylase and then repaired, but only after replication has occuredc) Two rounds of replication occur, followed by repair

Question

Biology

Esteban Choi

2 April, 23:19

For the nucleotide sequence AAC (O6-meG) TGCAC, with a damaged (methylated) G residue, what would be the sequence of each strand of the double-stranded DNA in the following situations? a) Replication occurs before repairb) The DNA is acted upon by glycosylase and then repaired, but only after replication has occuredc) Two rounds of replication occur, followed by repair

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Answers (1)

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Iris Benson · Answer 1

The correct answer is option a) "Replication occurs before repair"

Explanation:

The origin of replication is a sequence that is recognized by the cell's machinery to propagate its genome material trough the DNA polymerase activity. The AAC sequence is one of the most common origins of replication recognized by the DNA polymerase. Therefore, in this case at which a methylated G residue is present right after the AAC sequence it is very likely that the double-stranded DNA will be replicated before the cell could repair the damage.