In tissues deriving energy anaerobically (such as rapidly exercising skeletal muscle), lactate, rather than pyruvate, serves as the end product of glycolysis.
Which of the following statements best explains why pyruvate is converted to lactate under these circumstances?
A. The mitochondrion is more permeable to lactate than to pyruvate.
B. Lactate, but not pyruvate, serves as a substrate for gluconeogenesis.
C. The conversion of pyruvate to lactate is accompanied by the production of ATP.
D. NAD + necessary for the glyceraldehyde phosphate dehydrogenase reaction is regenerated
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