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28 February, 18:56

Which of the answer choices is/are an example of post-translational modification?

1. marking proteins for enzymatic destruction

2. addition of a phosphate group to the side chains of amino acids such as serine, threonine, or tyrosine

3. All of these choices are correct.

4. addition of one or more sugar molecules to the side chains of some amino acids

5. assistance by chaperons in folding of newly translated proteins

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  1. 28 February, 21:24
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    4. addition of one or more sugar molecules to the side chains of some amino acids

    Explanation:

    Post-translational modification occurs after a polypeptide has been formed in the ribosomes after the translation of the mRNA. This involves the addition of other molecules to the chain other than the sequence of amino acids. Examples of post-translational modification are the processes of phosphorylation - adding a phosphate molecule - and glycosylation - adding a carbohydrate molecule. These modifications have significance including enabling the folding to the polypeptide to desired 3D shape, playing a regulatory function and stabilizing the protein.
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