Which of the following is the general guideline that IACUCs use to evaluate the potential pain of a procedure conducted with animals?

IACUCs (An institutional animal care and use committee) may be defined as the federal regulations for the institutions in which the animals are used for the research and study purpose.

Some laws, regulations and rules are made for the committees so that they cannot use the animals brutally and illegally. The procedure that might result in the pain and distress in human being can cause same in other animals as well.