Cancer is characterized by uncontrolled cell division. Cell division is preceded by DNA replication. Several proteins of the DNA-replication machinery can be targets for chemotherapeutic agents. One such protein is topoisomerase. Select the effects that result from the inhibition of topoisomerase. Supercoils accumulate, resulting in chromosomal instability.

Supercoils accumulate, resulting in chromosomal instability

Explanation:

Topoisomerase is an enzyme that plays an important role in DNA replication and packaging processes. It catalyzes a break in the DNA molecules, but uses covalent bonds to hold the broken DNA molecules. This enzyme controls the overcoiling of the DNA molecule. It is so named because it alters the topological state (binding number) of circular DNA, but not its covalent structure.

If this enzyme is inhibited, DNA strands will be damaged due to the production of supercoils that will result in chromosomal instability.