Ras, a small G protein located at the plasma membrane, is often mutated in different types of cancer. Ras normally signals to a cell that it should divide. Cancer cells divide uncontrollably. Which of the following changes to Ras would you expect to see in a cancer cell that has mutated Ras presentA. a mutation that means Ras cannot hydrolyze GTP to GDPB. a mutation that leads to Ras being sent to the endomembrane systemC. a mutation that means Ras cannot bind to GTPD. a mutation that means GDP is constantly bound to RasE. a mutation in which Ras cannot bind to its GPCR

Question

Biology

Amiyah Murillo

11 July, 22:46

Ras, a small G protein located at the plasma membrane, is often mutated in different types of cancer. Ras normally signals to a cell that it should divide. Cancer cells divide uncontrollably. Which of the following changes to Ras would you expect to see in a cancer cell that has mutated Ras presentA. a mutation that means Ras cannot hydrolyze GTP to GDPB. a mutation that leads to Ras being sent to the endomembrane systemC. a mutation that means Ras cannot bind to GTPD. a mutation that means GDP is constantly bound to RasE. a mutation in which Ras cannot bind to its GPCR

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Answers (1)

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Davian Sexton · Answer 1

A. a mutation that means Ras cannot hydrolyze GTP to GDP

Explanation:

Since Ras will remain in its active Ras-GTP form, Ras will continue to tell the cell to divide even when it is not correct to do so. This likely happens in cancer cells because of mutations in the Ras gene producing a Ras protein which can no longer be in its "off state" Ras-GDP.