Loss of equilibrium and motor coordination would most likely be related to a lesion in which structure?

Cerebellum

Explanation:

The cerebellum is the structure responsible for coordinating the activities of skeletal muscles. Its activities are related to equilibrium and body posture.

The cerebellum works in connection with the cerebral cortex and brainstem, in senses such as touch, sight, and hearing, on an unconscious level, from information received.

Individuals with cerebellar injury may exhibit loss of equilibrium, weakness and loss of muscle tone, as well as uncoordinated movements.