In a hemoglobin variant known as hemoglobin Kansas, an Asparaginein
the beta chain is replaced by a Threonine. This results in
thedisruption of a hydrogen bond that normally stabilizes the
R-stateof hemoglobin. Which statement is FALSE regarding the effect
thisamino acid change has on the ability of hemoglobin Kansas to
bindoxygen?
a. Inhemoglobin Kansas, there is an increase in the amount of
R-stateand a decrease in the amount of T-state.
b. In hemoglobinKansas, there is a decrease in the amount of
R-state and anincrease in the amount of T-state.
c. The R-state inhemoglobin Kansas is less stable than
normal.
d. The presence ofless oxy-Hb in hemoglobin Kansas indicates this
type of Hb has alower affinity for oxygen.
e. The p50 forhemoglobin Kansas is higher than normal.
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