A nucleosome forms hydrogen bonds with what part of the DNA? A nucleosome forms hydrogen bonds with what part of the DNA? only with bases via the major groove with the phosphodiester backbone and with bases via the minor groove only with bases via the minor groove with the phosphodiester backbone and with bases via the major groove

A nucleosome forms hydrogen bonds with the phosphodiester backbone and with the bases through the minor groove. The histone-fold hydrogen bonds with both the A: T enriched bases and the phosphodiester backbone. The histone-fold domains' association with the minor groove is responsible for the majority of the associations in the nucleosome.