Suppose both a group of people with a heritable disease and a control group without the disease are tested for their genotype at the disease locus and their genotype for a large number of different SNPs (single‑nucleotide polymorphisms). The disease locus is later determined to be in linkage disequilibrium with one SNP in particular. At what frequency are the disease allele and a particular nucleotide variant of the SNP found together, compared to the frequency expected by chance?

Question

Biology

Kinsley Butler

19 November, 13:17

Suppose both a group of people with a heritable disease and a control group without the disease are tested for their genotype at the disease locus and their genotype for a large number of different SNPs (single‑nucleotide polymorphisms). The disease locus is later determined to be in linkage disequilibrium with one SNP in particular. At what frequency are the disease allele and a particular nucleotide variant of the SNP found together, compared to the frequency expected by chance?

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Answers (1)

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Lucia Daniel · Answer 1

Higher.

Explanation:

SNPs (single‑nucleotide polymorphisms) may be defined as the substitution of the single of the single nucleotide at the particular position in the genome of the organisms.

The diseased people and the control group both are used in the experiment to determine their SNPs. The expected frequency is less than the diseases allele variant of SNPs. The disease variant has higher frequency when compared with the frequency occurred by chance.

Thus, the correct answer is higher.