Explain why the change in the way that molecules of b globin interact with each other lead to the sickling of the red blood cells in sickle cell anemia

The sickle form of the hemoglobin gene is created when an adenine nucleotide is changed to a thymine ... That single amino acid replacement in the - globin protein alters the shape and the chemistry of the hemoglobin molecule, causing it to polymerize and distort the red blood cell into the sickle shape.