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28 May, 08:30

A man and a woman are both carriers for two autosomal recessive disorders, PKU (chromosome 12) and cystic fibrosis (chromosome 7). If they have a daughter, what is the probability that she will have PKU but not CF?

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  1. 28 May, 10:57
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    Pr = (3/16)

    Explanation:

    It was stated that both the man and the woman are both carriers for two autosomal recessive disorders, PKU (chromosome 12) and cystic fibrosis (chromosome 7).

    ∴ let Aa¹Bb° represent the traits in the Man

    Where;

    Aa¹ = carrier of PKU

    Bb° = carrier of cystic fibrosis

    Also, let Cc¹Dd° represent the traits in the woman

    Where;

    Cc¹ = carrier of PKU

    Dd° = carrier of cystic fibrosis

    Now, if Aa¹Bb° self-crossed, we'll have the F1 progeny as AB, Ab°, a¹B and a¹b°

    also, if Cc¹Dd° self-crossed, we have CD, Cd°, c¹D and c¹d° as their F1 progeny

    In the F2 generation, the dihybrid cross between the F1 generations will be:

    AB, Ab°, a¹B, a¹b° * CD, Cd°, c¹D, c¹d°

    ACBD, ACb°D, a¹CBD, a¹Cb°D

    ACBd°, ACb°d°, a¹CBd°, a¹Cb°d°

    Ac¹BD, Ac¹b°D, a¹c¹BD, a¹c¹b°D

    Ac¹Bd°, Ac¹b°d°, a¹c¹Bd°, a¹c¹b°d°

    Only (a¹CBD, Ac¹BD, a¹c¹BD) shows the probability that she will have PKU but not CF.
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