In a human cell, what would happen to DNA replication during interphase of the cell cycle if there were a single origin of replication in the entire genome?

The question is incomplete as it does not have the option which are:

No DNA replication would occur because DNA isn't replicated during interphase. All chromosomes would be replicated, but more slowly than usual. A single chromosome would be replicated. No DNA replication would occur because multiple origins of replication must interact to replicate DNA.

Answer:

All chromosomes would be replicated, but more slowly than usual.

Explanation:

Origin of replication refers to the sequence of the DNA in the genome of the organism where the process of replication begins.

The opening of the origin of replication allows the binding of the replisome complex at the terminals which initiates the process of the replication.

The number of origin of replication varies in the prokaryotes and the eukaryotes as the prokaryotes possess only one chromosome which requires only one origin of replication but eukaryotic chromosomes are large which contains multiple of origin of replication.

In the given condition if the chromosome contains only one origin of replication then the replication process will get slower as the large size of the eukaryotes will have to be replicated by only one Ori sequence.

Thus, the selected option is the correct answer.