Which of the following will be expected to be activated during times of prolonged starvation? (select all correct answers)

a. Gluconeogenesis in kidney

b. Lipogenesis in liver

c. Ketogenesis in liver

d. Lipolysis in adipose

e. Glycogenesis in muscle

f. Ketone utilization in brain

Option A

Option D

Option F

Explanation:

During the process of continuous starvation for a long period of time, the primary source of energy in body is hepatic gluconeogenesis which is responsible for producing endogenous glucose. Also lipolysis takes place in the adipose tissue to release fatty acid which is then converted into ketone bodies through though mitochondrial β oxidation and ketogenesis. The liver communicates with extrahepatic tissues, including adipose tissue and skeletal muscle and deliver glucose and ketone bodies to muscle and other extrahepatic tissues as fuels.

Hence, option A, D and F are true.