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9 November, 22:28

How would over expression of protein phosphatase 1 affect the induction of cAMP-inducible genes in response to hormone stimulation of target cells? Would protein phosphatase 1 affect the function of cAMP-gated ion channels? Why or why not?

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  1. 10 November, 00:26
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    The protein phosphatase-1 dephosphorylates the residues of serine, which are phosphorylated by the protein kinase A. The cyclic-AMP inducible genes are stimulated by CREB that is phosphorylated by protein kinase A. Thus, overexpression of protein phosphatase 1 would prevent their induction.

    Although, protein phosphatase 1 would not influence the function of cAMP-gated ligand channels, as these channels are opened directly by binding of cAMP rather than by protein phosphorylation.
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