The LPS, or endotoxin, of Neisseria gonorrhoeae is slightly different from most Gram-negative organisms because of the absence of repeating O-antigens; hence, it is called LOS instead of LPS. How could LOS be a major virulence factor for Neisseria gonorrhoeae

Neisseria gonorrhoeae the human pathogen that causes the sexually transmitted disease (STD) gonorrhea and is commonly transmitted by exchanging needles through the use of medications or by infected blood products.

LOS is a major virulence factor in Neisseria gonorrhoeae, since LOS causes autolysis during infection and the release of LOS endotoxin damages the host cells is the main cause of most gonorrhoea symptoms including greater frequency or urgency of urination, swelling or redness at the opening of the penis, and swelling or pain in the testicles ...