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12 June, 16:20

Pancreatic β cells release insulin from intracellular vesicles. This release is regulated in part by the activity of glucokinase. How would insulin release be affected if pancreatic β cells were mutated to express hexokinase rather than glucokinase?

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  1. 12 June, 17:10
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    Beta cells (β cells) are a type of cell found in pancreatic islets, synthesising and secreting insulin and amylin. Beta-cell mass and function diminish in patients with type I or type II diabetes, resulting in inadequate insulin secretion and hyperglycemia.

    If hexokinase was expressed rather than glucokinase, the release of insulin from pancreatic β cells would be constant, and changes in serum glucose would not affect the expression of insuline.
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