Which of the following are the main mediators/initiators of type II hypersensitivity reactions?

antibodies

mast cells

erythrocytes

histamines

Antibodies.

Explanation:

Hypersensitive reaction are intolerable reactions that are mainly occur due to exaggerated immune reactions. Autoimmunity and allergies are mainly produced in the hypersensitivity.

Type II hypersensitive reactions is generally mediated by the IgM or IgG antibodies. Antibodies bind to the target cell that are present as a host cell and result in the Type II hypersensitive reaction.

Thus, the correct answer is option (1).