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6 August, 18:37

Activation of the fatty acid (converting it to fatty acyl-scoa) requires the expenditure of 2 atps. use your answers from parts b and c to calculate the total number of atps generated from the metabolism of a saturated fatty acid with 16 carbon atoms including both the citric acid cycle and the β-oxidation pathway as well as the initial atp required to produce the acyl-scoa molecule that starts the process.

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  1. 6 August, 20:37
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    The right answer is 129 ATPs.

    The palmitate will pass 7 times by the β-oxidation associated with the respiratory chain. 7 successive acyl-CoA will be oxidized with 7 moles of oxygen producing 8 acetyl-CoA and will phosphorylate 35 moles of ATP.

    The 8 acetyl-CoA will be oxidized by the KREBS cycle and the mitochondrial respiratory chain, with 16 moles of oxygen producing 16 bicarbonates while 96 moles of ADP will be converted to ATP.

    So, we have 96 + 35 = 131 ATP.

    If we subtract the 2 ATP due to the activation of the fatty acids, we will have 129 ATPs (131 - 2) produced by a fatty acid with 16 carbons.
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