Cystic fibrosis is caused by a defect in which of the following transport proteins?

A) aquaporin

B) Na+-K + pump/ATPase

C) CFTR

D) Na/glucose co-transporter

E) ouabain

CFTR

Explanation:

Cystic fibrosis transmembrane conductance regulator (CFTR) is a transport protein that is responsible for the regulation of chloride ions transport in the epithelial layer. A mutation in the CFTR gene that leads to the encoding of a faulty CFTR protein is responsible for causing cystic fibrosis. In cystic fibrosis the regulation of chloride ions by the CFTR transport protein becomes abnormal and these lead to the disruption of salt and water transport in and out of the cell. This defect is thus responsible for the buildup of mucus in the lungs and the digestive tract that is a major characteristic feature of cystic fibrosis.

C) CFTR

Explanation:

Cystic fibrosis

It is basically a genetic disorder, which affects few parts of the body like, the pancreas, kidney, intestine, liver and the part which is most affected is the lungs.

The long term problem associated with this disorder is coughing up mucus and breathing problem, sinus infection, clubbing of the fingers, fatty stool.

It occurs due to the presence of mutations in the genes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein.

CFTR is responsible for sweat production, digestive fluids, and mucus. When the CFTR is not functional, secretions become thick. The condition is diagnosed by a sweat test and genetic testing.