Pre-leukemia myelodysplastic features in acute myeloid leukemia may include.

A) Hypergranular neutrophils

B) Hypogranular neutrophils

C) Plasmacytoid cells

D) Monocytoid cells

E) None of the above

B) Hypogranular neutrophils

Explanation:

Myelodysplastic syndrome occurs due to a disordered production of blood cells in the bone marrow that die before they are even released into the bloodstream. This syndrome is of great clinical significance as they may progress to Acute Myeloid Leukemia. Generally, when this disease has pre-leukemic features it may include hypogranular neutrophils which is one is a feature of neutrophil dysplasia commonly observed in myelodysplastic syndromes.