In a person with MCAD deficiency, if the body has excess glucose stores, which electron transfer intermediates are likely to accumulate? How does this change if the body is energy depleted?

Question

Biology

Briley

2 May, 19:56

In a person with MCAD deficiency, if the body has excess glucose stores, which electron transfer intermediates are likely to accumulate? How does this change if the body is energy depleted?

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Raelynn Wu · Answer 1

In high glucose-NADH and FADH2

In depletion case - NAD + and FAD+2.

Explanation:

MCAD (Medium-chain acyl-CoA dehydrogenase) deficiency may be defined as inherited disorder in which the body's ability to breakdown the fat decreases and converting them in energy.

Excess glucose stores: The presence of excess glucose prevents the proton gradient to transfer electrons in the electron transport chain. This causes the buildup of NADH and FADH2.

Low energy state: This state needs ATP that decrease the carriers and causes the buildup of NAD + and FAD+2.