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9 October, 10:13

teractions between cyclins and cyclin-dependent kinases control the cell cycle. Explain how the presence or absence of inhibitors of cyclin-dependent kinases might play a role in normal cells becoming cancer cells.

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  1. 9 October, 13:53
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    Cyclins are proteins that bind to kinases (i. e., cyclin-dependent kinases), by acting as their cofactors. The cyclin-dependent kinases play critical biological functions such as, for example, the regulation of the cell cycle, mRNA processing, etc. The inhibitors of cyclin-dependent kinases are able to alter the cell cycle progression and thereby inhibit cell death (apoptosis), which is common in cancer cells.
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