Naproxen has been prescribed to a client whose increasingly severe migraines are interfering with work performance and family life. when providing health education to this client, the nurse should instruct the client to consider what intervention?

The right answer is to take the medication during a meal.

The therapeutic properties of non-selective NSAIDs are based on the inhibition of cyclooxygenases (COX 1 and 2) which are enzymes that convert arachidonic acid into prostaglandins.

Inhibition of the synthesis of gastroduodenal prostaglandins alters the defense mechanisms of the mucosa and thus promotes the occurrence of ulcers, usually gastric and duodenal.

Inhibition of prostaglandins will initially result in a decrease in mucosal blood flow. Polynuclear adhesion to the wall then results, leading to endothelial lesions and accentuating the decrease of the mucosal blood flow, thus favoring the inflammatory process in the digestive mucosa.

The inflammation is amplified by the production of TNF-Alpha stimulated by anti-inflammatory drugs in macrophages.