Which of the following is a factor that, by itself, does not promote widespread changes in allele or genotype frequencies? a. New mutation d. Migration b. Natural selection e. Nonrandom mating c. Genetic drift

A new mutation

Explanation:

A mutation refers to the random changes in the DNA of organisms. A mutation changes the allele and genotype frequencies by the introduction of a new allele in the gene pool.

However, mutations are not the major factor responsible for changes in the gene pool of a population as mutations are rare. The rate of mutations is very slow and does not allow it to serve as a major factor to change the allele and genotype frequencies.