Both insulin and glucagon are peptide hormones that target liver cells. The response of the target cells to each of these two hormones is opposite. This information implies that

Answer;

-The two hormones bind to different receptors and use a different second messenger.

Explanation;

-Most hormones circulate in blood, coming into contact with essentially all cells. However, a given hormone usually affects only a limited number of cells, which are called target cells. A target cell responds to a hormone because it bears receptors for the hormone.

-Insulin and glucagon are hormones secreted by islet cells within the pancreas. They are both secreted in response to blood sugar levels, but in opposite fashion.