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27 May, 19:49

From the list below, which event leads to activation of NF-κB?

Question 1 options:

A)

selectin binding

B)

S-Lex interactions

C)

integrin activation

D)

TLR activation

E)

ICAM activation

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Answers (1)
  1. 27 May, 20:01
    0
    (D). TLR activation.

    Explanation:

    Nuclear factor kappa light chain enhancer of activated B cells (NF-κB) represents a protein complex, which plays various roles in activation of adaptive and innate immune response.

    TLRs (toll-like receptors) are specific pattern recognition molecules found in pathogens that triggers immune responses. TLR activation stimulates activation of NF-κB signalling by triggering a downstream signaling cascades.

    Activation of NF-κB signalling leads to upregulation of various pro-inflammatory substances or cytokines.

    Thus, the correct answer is option (D).
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