Ralph is always thirsty and recently learned that he synthesizes mutated antidiuretic hormone (ADH). Discuss why Ralph would be at risk for insipidus diabetes

Diabetes insipidus is a disease characterized by excessive thirst and the excretion of large amounts of highly diluted urine, which can not be reduced by a reduction in fluid intake.

Diabetes insipidus is due to a deficiency of antidiuretic hormone or insensitivity of the kidneys to this hormone. This hormone causes water reabsorption via action on the distal segment of the nephron during dehydration.