Parental permission should be waived for research in gsd youth when:

It might be. In general, parental or guardian permission should be sought before seeking the assent of a child, particularly in more than minimal risk research, unless the requirement for obtaining parental or guardian permission can be waived. There might be some cases, however, involving minimal risk research, where it would be reasonable to seek child assent prior to seeking parental permission.

The correct answer to this open question is the following.

Parental permission should be waived for research in GSD youth when research protocol is designed to examine conditions in children when familial approval is not a sound condition to protect the subjects. Under some cases, an Institutional Review Board may waive the terms for obtaining parental consent.