Based on your knowledge of signal amplification, which type of chemical messenger can have relatively small concentrations within the bloodstream and still get a large compensatory response

The correct answer is lipophobic signal messenger.

Lipophobic signal molecules cannot enter cells by simple diffusion through the cell membrane and because of that, these signal molecules bind to receptor proteins on the cell membrane. The response time for pathways linked to membrane receptor proteins is very rapid-within milliseconds to minutes.