What is different about synthesis of lagging strand compared to synthesis of the leading strand? A) synthesis of leading strand does not occur in 5 * to 3 * direction. B) Synthesis of lagging strand does not use DNA polymerase C) Synthesis of lagging strand does not use base pairing D) Synthesis of the leading strand does not involve RNA primers and Okazaki fragments

The difference in synthesis of lagging strand compared to synthesis of the leading strand is D) Synthesis of the leading strand does not involve RNA primers and Okazaki fragments. DNA polymerase adds nucleotides at the 3' end toward the 5' end in the direction 3' to 5'. The free end of the lagging strand is 5' so DNA polymerase cannot start from that end. The replication of the lagging strands is discontinuous and it involves RNA primers and Okazaki fragments. Synthesis of the leading strand is under control of DNA polymerase.