The shape of a protein is primarily determined by

a) type and sequence of amino acids

b) size

c) cell location

The best answer is A.

The shape of a protein is determined by its primary structure. The primary structure is the sequence of amino acids in each polypeptide chain which make up a protein.

The sequence of amino acids is basically a list of amino acids that are linked to each other to form a chain which is known as a polypeptide chain.

The structure of the finished protein will depend largely on the first (primary) chain of amino acids to be produced to make up that protein.