Initiation of replication occurs at an origin of replication site that typically includes an at-rich region. initiation benefits from these at-rich regions because

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In the process of initiation, what happens is that the proteins bind to the replication source or origin. And in this process, it includes the AT-rich region. How initiation gains from this regions is that two H-bonds hold the adenine-thymine pairs together. This makes it easier to separate in the unwinding process.