For a specific enzyme/substrate system, which condition will always result in an increase in Vo (assuming nothing else changes) ?

a decrease in Km and an increase in Vmax

km is the constant that relates how thick the volume of the substrate in terms of concentration when the speed is a large portion of the most extreme. They increment Km by meddling with the joining process that makes them stick together wit the substrate, however they have any effect with regards to Vmax since since the sticking process to ES did not occur