Using retosynthetic analysis, complete the synthesis of 2-pentanone from ethanol, proceeding through a keto ester as the synthetic intermediate. g

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Chemistry

Kiara Shaw

22 October, 19:35

Using retosynthetic analysis, complete the synthesis of 2-pentanone from ethanol, proceeding through a keto ester as the synthetic intermediate. g

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Johanna Hensley · Answer 1

Step 1:

Esterification:

Butyric Acid is treatet with ethanol in the presence of Acid. The corresponding intermediate formed is Keto Ester (Ethyl Butyrate) and serves as a synthetic intermediate. (Highlighted RED in scheme).

Step 2:

Nucleophilic Substitution Reaction:

The corresponding Ester formed is treated with Methyl Magnesium Bromide. And after hydrolysis 2 - Pentanone is synthesized. The r2 step reaction is shoen belo.