Which factors would negatively impact the bodies digestive system

Sugar - it is heating, sticky and toxic to the body in big doses

Lack of sleep - your body needs adequate rest to rejuvenate all organs so they can perform their intended roles

Over-eating - this can send your body into shutdown mode and put excess stress on your organs

Alcohol - both poisonous and toxic to the body, too much alcohol damages the body internally which is evident externally

Cold food and drinks - can create stagnation in the digestive system, slowing down the digestive process considerably

Emotions - anger/upset/frustration - all will affect one or more of your organs. Try and control what you can and let go of what you can’t

Processed foods - they contain foreign properties that are literally indigestible by the human body

Pandadol/nuerofen - contain chemicals that will alleviate pains and complaints temporarily, yet will leave a trail of destruction. Try natural remedies instead

Anti-biotics - whilst they kill bacteria and bugs - they also kill your insides! Follow up a round of anti-biotics with some gut nourishing foods

Over-exercise - will deplete your Qi and deplete your digestive strength. Exercise is fantastic in decent doses - not extremes. Are there issues in your life that you are avoiding and using exercise as a distraction from?

I only listed 10 examples for you because you didn't put any more detail on a specific number or answer.