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10 April, 14:55

Consider phosphofructokinase, which statement is true? Group of answer choices

None of the above.

High ATP inhibits the enzyme; fructose-2,6-bisphosphate activates the enzyme.

Low ATP activates the enzyme; fructose - 2,6-bisphosphate inhibits the enzyme.

High ATP activates the enzyme; fructose - 2,6-bisphosphate inhibits the enzyme.

Fructose - 2,6-bisphosphate and ATP inhibit the enzyme.

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Answers (1)
  1. 10 April, 18:16
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    High ATP inhibits the enzyme; fructose-2,6-bisphosphate activates the enzyme.

    Explanation:

    PFK-1 inhibitors are ATP and Citrate which is an intermediate metabolite of the aerobic cycle while the activators responsible for reversing such inhibition caused by ATP are ADP, AMP and Fructose - 2,6-bisphosphate. The lats one is a powerful activator of PFK-1 but in the liver.
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