How is it possible for a protein to change over 70% of its amino acids and still fold in the same way?

Question

Chemistry

Lucero

1 December, 20:29

How is it possible for a protein to change over 70% of its amino acids and still fold in the same way?

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Hayden Freeman · Answer 1

The complete question is

Comparison of a homeodomain protein from yeast and Drosophila shows that only 17 of its 60 amino acids are identical. How is it possible for a protein to change over 70% of its amino acids and still fold in the same way?

Answer:

Many different strings of the amino acid can give rise to the identical protein folds. The amino acid differences between the Drosophila and homeodomain proteins from yeast are the functional proteins which do not change their structure and function.

There is a several amount of folding required which can cause change in the protein structure.

There is a basic functional proteins common in both the organism which do not change its structure and function.