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21 May, 17:37

What alteration to an HCN channel will reduce the transport of K + in favor of Na + transport? HCN channels are permeable to both K + and Na + ions.

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  1. 21 May, 19:35
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    Decreasing the diameter of the channel by removing aa's. Since Na + is chemically similar to K+, one can assume the difference must be due to the size of the atom. The K + ion is larger than the Na + ion, so reducing the diameter of the channel can allow Na + to enter while preventing K + entry. This explains clearly and perfectly how reducing the diameter reduces the

    transport of K + in favor of Na + transport.
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